Formulation and Evaluation of Mucoadhesive Buccal Drug Delivery System of Metoprolol Tartrate by Using Central Composite Design
نویسنده
چکیده
significant effect on bioadhesive strength and in vitro drug release. It was found that carbopol gives higher bioadhesive strength than HPC. Comparatively HPC controls the drug release greater than carbopol. The optimized formulation follows non-Fickian release mechanism. The FT-IR and DTA studies indicate no physico-chemical interaction. Stability studies revealed that optimized formulation was stable. The predicted values of drug release at 8 hrs, bioadhesive strength, T release exponent, n are 64.26%, 44.84 gm, 6.10 50%, hrs, 0.658 and actual values are 60.45%, 43.52 gm, 6.46 hrs, and 0.673 respectively.
منابع مشابه
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